Growth hormone deficiency (GHD) in children is defined as growth failure associated with inadequate growth hormone production. Before considering growth hormone deficiency as a possible diagnosis, a child with growth failure needs to be evaluated for more common conditions that can impact growth.
Growth hormone (GH) is a protein made by the pituitary gland and released into the blood in brief pulses. The major way that GH promotes growth is by increasing levels of the hormone, insulin-like growth factor-1 (IGF-1), and its carrier protein, IGF binding protein-3 (IGFBP-3), in the blood. GH and IGF-1 work together on the cartilage cells of the growth plate in long bones to increase bone length leading to increased height.
Growth hormone deficiency (GHD) in children is defined as growth failure associated with inadequate growth hormone production. Growth failure should be evaluated in children whose length or height remains below the normal range (i.e. <3rd percentile) or whose length or height percentile is falling and is crossing major percentile landmarks over time. Before considering growth hormone deficiency as a possible diagnosis, a child with growth failure needs to be evaluated for more common conditions that can impact growth. Growth failure can occur in children who have inflammation (recurrent illnesses, arthritis, inflammatory bowel disease, etc.), poor nutrition (inadequate intake or malabsorption conditions such as celiac disease, cystic fibrosis, etc.), other chronic conditions (psychosocial short stature, chronic renal insufficiency, liver disease, hypothyroidism, etc.) and genetic conditions that impact growth (skeletal dysplasias, familial short stature, Russell-Silver Syndrome, Turner Syndrome, etc.). Children receiving stimulant therapy for attention deficit and hyperactivity disorder may have impairment of growth, particularly if caloric intake is significantly affected. However, stimulant therapy does not cause GHD. Chronic glucocorticoid therapy (inhaled or oral) can cause significant growth failure. Children with constitutional delay of growth and puberty (“late-bloomers”) can have growth failure that may be difficult to separate from GHD.
Screening tests for GHD in children with growth failure with no identified cause include bone age X-ray and serum IGF-1 and IGFBP-3 levels. A delayed bone age is more common in children with GHD. An IGF-1 in the low part of the normal range or below normal increases the likelihood of GHD. An MRI picture of the brain showing a small or ectopic (misplaced) pituitary gland supports a diagnosis of GHD. The gold standard for diagnosing GHD is failure to increase GH levels in a growth hormone stimulation test (GHST). A GHST is performed in children after an overnight fast by giving a medication or medications (such as insulin, clonidine, arginine, glucagon, L-Dopa, etc.) to cause release of growth hormone into the blood and drawing blood frequently. If the highest growth hormone level obtained following two separate stimuli is less than 10 ng/mL, this is diagnostic of GHD. However, GHST is not required for diagnosis of GHD if other clinical parameters are present. Isolated congenital GHD may be associated with low blood sugars in infants and a small penis in male infants. Congenital GHD may be also be associated with multiple other pituitary deficiencies in infants and is increased in children with optic nerve hypoplasia and midline defects including cleft palate.
Diagnosis & Treatment
Children diagnosed with GHD benefit from GH replacement therapy with improved linear growth until the growth plates fuse. rhGH therapy is given by daily subcutaneous injections. Children and their families are taught to self-inject rhGH at home. The rhGH starting dose is based upon the child’s weight and may be adjusted during therapy based upon weight gain, growth response and IGF-1 levels. Children receiving rhGH therapy should be seen by the pediatric endocrinologist every 3 to 6 months for monitoring of growth and adjustment of the rhGH dose. The earlier a child is diagnosed with GHD, the better the final height attained and the higher the likelihood that the child will reach a height that is normal for an adult. Some children with severe GHD will require rhGH therapy as adults due to the metabolic effects of GH.
How GH Affects the Body Other Than Growth
In addition to growth, growth hormone regulates the metabolism. As calories are consumed, growth hormone controls whether those calories are used to build bone, muscle and cartilage or stored as fat. Between meals, growth hormone regulates mobilization of fat for use as energy. Growth hormone deficiency is a condition that involves impaired linear growth and significant metabolic differences including changes in body composition (decreased bone mass, decreased lean mass and increased visceral adiposity) and lipid profile (elevated LDL cholesterol and triglycerides). In children with growth hormone deficiency, growth hormone replacement therapy is important to normalize the metabolism and maximize these metabolic benefits. If a child stops growth hormone prematurely, he/she will not be able to gain the benefits of maximal bone mineral accrual and lean body mass during his pubertal growth spurt and will have increased visceral adiposity and abnormal lipid profile; this can have a negative long-term impact on his/her bone and cardiovascular health.
Contributing Medical Specialist
Bradley S. Miller, MD, PhD
University of Minnesota Masonic Children’s Hospital
Medical Advisory Committee Member
The MAGIC Foundation
If you picked up this brochure, it is likely that you have concerns about the physical growth of someone close to you. Physical growth is often a sign of a child’s overall health. Given that growth is connected in many ways to health, it is important for children who are not growing at a rate considered within average range to be evaluated by medical personnel (1). For children who are extremely short compared to their same age peers, evaluation of height and possible related health issues is vital.
Short Stature and Social-Emotional Development
Children who experience growth delays may be treated younger than their chronological age by peers, caregivers, educators, and others. Unfortunately, people often judge others by their appearance. People make assumptions based on how people look, how tall they are, and even how much they weigh. For many children with delayed growth, people associate height with age. When children are much shorter than their peers several things can happen. Adults and peers treat the child as younger which may interfere with psycho-social development. When behavioral and academic expectations are lowered based on height rather than chronological age, children may not learn the appropriate and expected behaviors for a child their age. Children often behave in a manner that is expected. If a child is treated as if they are younger than their chronological age, the child is likely to behave as a younger child would behave. If this pattern continues a child is likely to lag behind their peers in social, behavioral, and emotional maturity (6).
School Issues and Concerns
Most parents, regardless of their child’s growth, have questions about their child’s academic ability and achievement. Children with growth delays, much like children with other chronic conditions, appear to have variability in their academic achievement and school issues similar to the general population. However, several researchers have indicated that children with growth disorders, particularly those with co-occurring health issues or disabilities are at increased risk for academic difficulties and psychosocial issues (3, 4, 5, 7). Additionally, children who are significantly shorter than their peers may be an easy target for bullying. Parents and educators play a huge role in identifying possible academic difficulties including learning issues, attention issues, and social/emotional issues. If parents have any concerns about their child’s academics, intellectual abilities, physical or emotional health, social/relational development, or access to supports and services they should speak to their child’s school counselor, school nurse, teacher, or administration. The school has a responsibility for identifying children with learning needs and should follow up if the parents are concerned about their child. School counselors, teachers, and other personnel can be a tremendous source of support for children and their parents. If children are identified as struggling academically or behaviorally in school they will often be referred for further evaluation by a school psychologist or other professionals to identify learning, behavioral, or emotional issues.
Tips for Parents and Caregivers
Children often react to the emotions of their caregivers. Having a child with a significant medical condition can create stress and anxiety for parents, siblings, and extended family (8, 9, 10, 11). Parents and caregivers need to make sure they are practicing good self-care while at the same time providing the medical, health, social, and emotional support for their affected child as well as their other children. Siblings may experience stress, become worried and anxious, or may feel they must take on additional responsibilities to help ease the stress on their parents (11). Professionals recommend that parents pay attention to siblings’ emotional reactions and health as they have increased risk for depression and anxiety (11). Children with growth delays often face many medical tests and procedures which can be frightening and/or painful. Repeated hospitalizations due to tests, illnesses, medical procedures, or complications from a chronic medical condition can create chaos and stress for the entire family (10). Children, particularly young children, who experience repeated stressors or chaotic environments (i.e. hospitalizations, surgeries, repeated medical procedures) may be at increased risk for anxiety, depression, and stress related conditions (12). Finding ways to reduce stress for all family members is important.
Create and stick to a routine as much as possible. Children are less stressed when they are in predictable environments with similar mealtimes, bath times, bed times, etc. Even when there is some kind of medical upheaval, it is helpful to try to maintain routines to the best of your ability (10). Adults can lower the stress by bringing along a favorite book, sleepy toy, pillow, etc. In addition, if you have the luxury of extended family or caregivers, it may help reduce sibling anxiety if children are able to stay in their own home and in their own bed while the affected child is in the hospital or traveling for medical treatment. Try to keep routines similar even when there are hospitalizations, medical treatments, or travel involved.
Develop or maintain a sense of humor. Humor can reduce tension and stress. Humor allows us to see the funny things that happen and can help us laugh at situations rather than treat them like they are the end of the world. Laughter is good medicine. Sometimes we need to learn not to take things so seriously. Pick your battles wisely and learn to laugh at absurdities.
Provide a supportive and safe environment but avoid becoming a helicopter parent. It is easy to become an overprotective parent when you have a child that is ill or can become ill or is injured easily. Put supports and safety measures in place, develop an emergency action plan to leave for babysitters and caregivers (even yourself), and create back up plan. Then, live life to the fullest. Allow kids to be kids and allow yourself, as a parent, to have time for respite, fun, and relaxation. We cannot prevent every illness, every sickness, every mistake, or every accident. If you bubble wrap your child you may unintentionally lower their self-esteem and resilience.
Be firm and consistent with discipline and boundaries. Even when children face challenges they need consistent discipline and boundaries. Consistent boundaries and rules help children know what to expect (10, 13). Over indulging children, spoiling them, and excusing their behaviors will not help them develop age appropriate behaviors that are so important in establishing and maintaining friendships. Learning to stay within boundaries helps children develop impulse control, learn interpersonal boundaries, and respect.
Learn to recognize typical verses atypical behavior. When parenting a child with a chronic illness or disability, parents are sometimes hyper alert to their behavior and development. While this can be helpful, it can also make us more prone to worrying about whether our child’s behavior is typical or not. There are great resources available to help guide you about when to become concerned about your child’s behavior based on their developmental level (10, 13). Remember, that you may have to “adjust” for age if your child was born prematurely or spent their first few weeks/months in the NICU.
Know when to be concerned and seek help. Most of the time, children with growth delays, their siblings, and their parents do just fine. However, having a child with a chronic medical condition puts extra stressors on everyone in the family and sometimes family members may need a little extra outside help (9, 13) . Below are some tips for when to seek help.
If the affected child or siblings:
· Experience unusually high levels of anxiety (9)
· Appear depressed, are overly sad for long periods of time, do not seem to enjoy things that once brought pleasure, withdraws from friends or activities (9, 13)
· Seem to feel guilty or overly responsible for the affected child’s health (9, 13)
· Acts out, seeks out attention inappropriately, or becomes disruptive (9)
· Threatens to harm self or others
· Gets into fights, throws things, or tries to harm self, others, or animals (9)
· Grades fall or the child demands perfection in all their school work and/or activities (13)
· Has meltdowns, lashes out in anger, or cries often over minor things
· Uses alcohol or drugs
· Seems to need coping skills or someone to talk to (9, 13)
· Other behaviors that persist and seem out of character that concern you
Counselors, clergy, school counselors, pediatricians, and other professionals can guide you in finding help for your affected child, siblings, and even yourself as the caregiver. Remember that emotional and psychological health impacts physical health. Continued stress can be harmful so make sure to seek help when needed.
Having a child with a growth delay or growth disorder can be challenging physically and emotionally (8, 10, 13). Parents and caregivers often feel stressed (8, 10, 14). and want to make sure they are doing all they can to ensure their child’s physical and emotional well-being. If you have questions or concerns about the growth of a child or how you can support and nurture a child with a growth delay or disorder contact MAGIC for information, resources, and support.
Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia is an autosomal recessive genetic disorder, which means that it affects males and females in equal numbers, and that it requires both parents to pass on a gene in order for it to manifest as a disease. For a child to be born with any form of CAH, both parents must carry a gene for the disorder.
Growth Hormone Deficiency
Growth hormone (GH) is a protein made by the pituitary gland and released into the blood in brief pulses. The major way that GH promotes growth is by increasing levels of the hormone, insulin-like growth factor-1 (IGF-1), and its carrier protein, IGF binding protein-3 (IGFBP-3), in the blood.
Optic Nerve Hypoplasia
A child with the Syndrome of Optic Nerve Hypoplasia, also known as Septo Optic Dysplasia or DeMorsiers Syndrome, has under-developed optic nerves. The optic nerves carry messages from the eye to the brain. ONH is the single leading cause of blindness in infants and toddlers.
Russell Silver Syndrome
Russell-Silver syndrome (or Silver-Russell syndrome) is a rare genetic disorder characterized by delayed growth in-utero (IUGR) that spares head growth (meaning the newborn has a head size that is large for his body) and ongoing postnatal growth failure.
Small for Gestational Age
SGA (small for gestational age) generally describes any infant whose birth weight and/or birth length was less than the 3rd percentile, adjusted for prematurity (gestational age). Between 3% and 10% of live births each year are diagnosed as SGA.
Turner’s Syndrome occurs in 1 in 2,500 live female births. Approximately 98% of pregnancies with Turner’s Syndrome abort spontaneously and approximately 10% of fetuses from pregnancies that have spontaneously aborted have Turner’s Syndrome.
Connect with us!
We have created a Facebook page called Omkar’s Journey with Congenital Adrenal Hyperplasia to chronicle all possible events and scenarios in the life of a child with CAH, with a view to let new parents know what to expect.
➤ Step 1: Search for the group page on Facebook.
➤ Step 2: Please request to join.
➤ Step 3: Send a message to the Admin or an email to
[email protected]://www.https://www.https://www.https://www.magicfoundation-india.org and let us know why you are interested in joining this group.